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Development History After the discovery of GHK-CU in the 1980s, researchers quickly identified limitations: the peptide was fragile, broke down when exposed to other skincare ingredients, and had limited penetration depth

These ranges come from allometric scaling of the animal work plus anecdotal reporting not human trials so anchor your expectations to that

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The peptide sequence, derived from human growth hormone, appears sufficiently similar to native proteins that the immune system does not mount a response against it

Studies indicate possible nootropic effects through enhanced cellular energy metabolism, improved mitochondrial function, and reduced oxidative stress