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That meal causes a much bigger, longer LPS response Your immune system burns a ton of energy fighting that response, which is why you feel sluggish and sleepy after bad meals LPS also binds to LDL particles, makes them harder for the liver to recycle, and they get stuck in artery walls Macrophages arrive thinking it is a bacterial invader

They also are sensitive to environmental conditions and can change chemical composition if stored at the wrong temperatures or shaken too vigorously, increasing the risk of an immune response or decreasing their effectiveness

Tran D, Tran PA, Tang YQ, Yuan J, Cole T, Selsted ME: Homodimeric -defensins from Rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides

The date on the label is based on stability testing, and extending past it is guessing

This chronic inflammatory disease of the soft and hard supporting tissues of the teeth is periodontitis, which is one of the most frequent human diseases (3, 4)