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Evaluation of the skin irritation using a DNA microarray on a reconstructed human epidermal model

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L-serine, on the other hand, is reversibly catalyzed to glycine and CH2-THF by SHMT1 or SHMT2 in the cytosol or mitochondria, respectively, and participates in one-carbon metabolism and the S-adenosine methionine (SAM) metabolic network through the transfer of one-carbon units ( Figure 1b ) ( Figure 1 Therefore, L-serine is a precursor molecule for the synthesis of many substances, and the metabolism of L-serine includes the synthesis of amino acids, phospholipids, and proteins ( Figure 1c ) (Zhang et al., 2018a

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Folic acid is absorbed almost completely when taken without simultaneous consumption of food, whereas its bioavailability from fortified foods or supplements ingested during a meal is about 85%