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Additionally, inhibitors of ceramide biosynthesis affect ABCG5/8 -mediated cholesterol transport, indirectly influencing bilirubin excretion, while UGT1A1 modulators offer targeted interventions for hyperbilirubinemia

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First-generation GHRPs such as GHRP-6 were identified through systematic screening of met-enkephalin analogs and demonstrated potent GH release but with significant off-target effects including appetite stimulation, cortisol elevation, and aldosterone release