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eBioMedicine 44, 691707

Nature 456 , 264268 (2008)

No serious adverse events related to skin sensitivity were documented, and no participants discontinued treatment solely because of this side effect

EV4E) and in whole skin lysate (Fig

It is worth noting that the evolution of Ca 2+ signaling dates back to prokaryotes, making it an important intracellular messenger regulating multiple cellular functions in all domains of life [193,194,195]