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They may work reasonably well for GI issues or systemic support, but bioavailability is less predictable

Front Endocrinol 13:1092837 Omon EA, Ajayi OD (2023) Oxidative stress and antioxidants markers in individuals with thyroid hormones dysfunction

The most performance-relevant outcome is improved oxygen delivery, because B12 deficiency directly causes anemia and reduced VO2 max regardless of training

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Conversely, administration of a selective CB1 antagonist suppressed food intake and weight gain in obese animals [56], suggesting that endogenous endocannabinoids may have an orexigenic effect