Biochim Biophys Acta (2000) 1488:16781
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This vulnerability is primarily due to the high content of PUFAs in their membranes, the limited availability of antioxidant enzymes, and the lack of effective DNA repair mechanisms
G., Steiner, J., Guest, P
Like at AMYRs, these features require the expansion of extracellular TM bundle of CTR through outward movements of TM1, ECL1/TM3, TM4/ECL2 and a small shift in the positioning of the mid-region of the peptide at the start of the N-terminal helix, relative to rAmy when bound to the CTR in the bypass conformation (Fig