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Pancreatic proteases release B12 in the small intestine where it then binds to intrinsic factor (IF), which is secreted by the parietal cells in the stomach

In the primary analysis using the trial product estimand, which evaluated participants who adhered to treatment, bodyweight decreased progressively in all active treatment groups over the 26-week period, without clear evidence of reaching a plateau

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"My stock answer is that we just don't have enough data to support their use."

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