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Cognitive improvement with intravenous HGF infusion in the APPswe/PS1dE9 mouse model of Alzheimers disease

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The ability of the cognitively active fragments described here to support hippocampal spinogenesis was tested and the results are presented in Figure 31A-D.As can be seen from the dose-response curves, each of the metabolically stabilized molecules supported hippocampal spinogenesis

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