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Understanding Ankle Anatomy and Common Injuries The ankle joint complex represents one of the most biomechanically demanding structures in the human body, supporting body weight while allowing the complex movements required for walking, running, and athletic performance

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Although reperfusion is critical for tissue repair, it triggers more severe injury via oxidative stress, inflammatory responses, and mitochondrial dysfunction [35]: hepatocytes endure hypoxia during ischemia, and reperfusion reintroduces oxygen, triggering a burst of reactive oxygen species (ROS), intracellular calcium overload, and increased production of pro-inflammatory cytokines/chemokines, which further exacerbate hepatocyte damage, apoptosis, and necrosis [36]

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