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Clinical research suggested doses in the range of 1-10mcg per kilogram of body weight showed efficacy, though most protocols standardized around 4-6mcg/kg for practical application

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Teens and adults should have 2.4 mcg of vitamin D, and the National Institute of Health recommends that pregnant women should have 2.6 mcg and breastfeeding women 2.8mcg

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Local injection may provide faster onset at specific sites while systemic dosing offers broader distribution