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New York: Plenum Press

Symptoms of nicotine withdrawal are at their worst during the The physical and psychological effects of nicotine withdrawal include: anxiety stress irritability trouble sleeping depression restlessness difficulty focusing increased appetite Once the physical symptoms are gone and all nicotine has left the body, a person may still feel a psychological desire to smoke

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We found that increase in serum 8-OHdG concentrations depended not only on the As-ADI but also on the number of cigarettes smoked per day

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