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Funding The authors thank the Agencia Nacional de Investigacin y Desarrollo de Chile (ANID)/CONICYT for the PhD scholarship No

For some outcome metrics, success will be considered closing part of the gap of the provider compared to the goal

For only GSSG quantification samples and the standard are treated with 4-vinylpyridine for an hour before performing glutathione assay and thus GSH is removed and only GSSG concentration is determined.

Further research is needed to elucidate the pathways involved in NO signaling within VSMCs exposed to high levels of uric acid, as this knowledge could contribute to the development of therapeutic strategies aimed at mitigating uric acid-induced vascular damage and hypertension

TX, XY, SZ, YWW, YFW, SN, and CZ organized the database and experiments