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These findings suggest that these glycosides possess an inhibitory effect on TRP metabolism into KNY, thereby promoting increased conversion of TRP to serotonin and exerting an antidepressant effect

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Hum Psychopharmacol Clin Exp 10:S107S118 Delbressine L, Moonen M, Kaspersen F, Wagenaars G, Jacobs P, Timmer C, Paanakker J, Van Hal H, Voortman G (1998) Pharmacokinetics and biotransformation of mirtazapine in human volunteers

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