Compared to the placebo group, those who received the silymarin saw a "significant decrease" in their levels of key diabetic markers hemoglobin A1C, fasting blood sugar, total cholesterol, low-density lipoprotein ("bad") cholesterol, and triglycerides.17 The second is a recent review published in the Annals of Hepatology in 2021, much of which relates to silymarin's effect on insulin resistance,18 a prominent marker for type 2 diabetes.19 Two of the studies referenced in the review were animal studies that administered 26.25-100mg/kg of silybin to rat subjects (equivalent to around 366-1,395mg for an 86kg, or 190lb, human) across 6-12 weeks
Hamilton and Attwell, 2010
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Mechanistic investigations associate these outcomes with signaling pathways involving vascular endothelial growth factor receptor-2 (VEGFR-2) and downstream Akt-eNOS activation, processes that collectively facilitate efficient muscle tissue remodeling (5)
Enhancing the immune system, reducing the risk of various diseases
