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The signal to grow still exists

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This is mechanistically different from injecting recombinant GH itself: a GHRH agonist raises GH indirectly, through the pituitary, so the output remains at least partly subject to the axiss normal regulation including negative feedback from IGF-1 and somatostatin

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Conversely, the CBBBP peptide alone demonstrated a less marked effect, indicating that the primary therapeutic benefits are attributable to the DSIP component