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Hormonal imbalances or conditions like polycystic ovarian syndrome (PCOS) can cause skin tone changes

Other studies in adults with metabolic syndrome have shown that it may reduce insulin resistance and lower fasting blood glucose and HbA1c levels

The duration of treatment was 5 days

Topical glycyl-histidyl-lysine copper complex in the treatment of aging skin: a double-blind, placebo-controlled study

Despite this, biological effects on VEGFR2 signaling, EGR-1 transcription, and tissue repair persist for hours to days after a single dose, suggesting effects are mediated by rapid signaling cascades whose downstream consequences outlast the parent compound