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14 Bupropion dosing recommendations for smoking cessation: 15 Step 1 set a quit date Step 2 initiate bupropion one to two weeks before this quit date, initially at a dose of 150 mg, once daily Step 3 after three days, increase the dose to 150 mg, twice daily (minimum of eight hours between doses)* Step 4 continue use of 150 mg, twice daily, for at least seven weeks in total (longer durations are acceptable, if needed, e.g