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In contrast, Nrf2 activators, such as sulforaphane, have been found to prevent homocysteine- or hydrogen peroxide-induced cataract formation in human lens epithelial cells by increasing nuclear translocation of Nrf2 and expressions of cellular antioxidants, including catalase, superoxide dismutase, glutathione peroxidase, and glutathione

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This sustained activation of amylin receptors produces continuous appetite suppression between doses, and cagrilintide weight loss data confirms the compound works even as a standalone treatment

Interestingly, immunofluorescence staining revealed profound F-actin contraction in glucose-deprived shGDH1 cells, which could be rescued by TCEP (Supplementary Fig