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Trends Plant Sci 11:424427 Bown AW, Shelp BJ (2016) Plant GABA: not just a metabolite

Considering that the pathogenesis of human and animal diseases may be completely different and animal models cannot predict the safety and efficiency of drugs on humans, clinical trials are essential for applying TCM drugs to induce ferroptosis for cancer therapy

Upon infection, HBV DNA enters the nucleus of the hepatocyte, where it serves as the reservoir for formation of virus particles for the lifetime of the cell and makes treatment of HBV challenging (Wilson 2009