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Cells appear to be continually exposed to the threat of L-ROS-mediated destruction, as inhibition of GPX4 activity leads to the rapid accumulation of L-ROS and cell death in cell culture, and deletion of Gpx4 in mice is embryonic lethal [6, 39]

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AMPK is a primary regulator of energy homeostasis and assists with the maintenance of metabolic homeostasis and flexibility

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