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These immune complexes contribute to mesangial cell proliferation and excessive production of extracellular matrix, cytokines, and chemokines, eventually leading to glomerular sclerosis (339341)

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It also prevents the solution from sitting against the stopper seal, which can degrade faster than the glass walls of the vial

However, consumption of any type of vegetarian diet dramatically increases the prevalence of vitamin B 12 deficiency in individuals across all age groups (127, 128)