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Since reactive oxygen species (ROS) primarily contribute to radiation-induced toxicity, antioxidant enzymes involved in ROS detoxification are expected to be influencing cellular radiosensitivity

The European Food Safety Authority (EFSA) has established an acceptable daily intake (ADI) of 3 mg/kg body weight (~210 mg/day for adults) as a conservative threshold (243)

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Small intestine conditions such as celiac disease, Crohns disease, parasite or bacterial growth

Additionally, the role of non-classical ferroptosis suppressors (e.g., FSP1, DHODH, and GCH1/BH4) in ADPKD is entirely unexploredwhether these pathways compensate for GPX4 downregulation in cystic kidneys or if their dysfunction exacerbates ferroptosis susceptibility remains unknown, limiting the development of multi-targeted interventions