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J Clin Med 12(4), 2023

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Jan 3, 2026 Dark circles under eyes create persistent cosmetic concern affecting appearance across all ages and skin types, with multiple underlying causes including thin periorbital skin revealing underlying vasculature, hyperpigmentation from melanin accumulation, shadows from volume loss and fat pad descent, and fluid retention creating puffiness accentuating darkness

-Lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway

For plasma biochemical profiles analysis, overnight fasting blood samples were obtained and centrifuged at 3000 r.p.m