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The IGF-1 axis is also mechanistically entangled with cell proliferation in ways that intersect with cancer biology, which is one reason the muscle-specific splice approach was originally pursued as a way to gain local anabolic signaling without the oncogenic side effects observed for IGF-1. [6] None of this constitutes a safety assessment for humans

& Hesso, A

Again, no significant change in transcript abundance was observed in infested susceptible plants when the same pair of primers unique to the genes was used for PCR

Regulation of insulin-like growth factor messenger ribonucleic acid in rat growth plate by growth hormone

Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways