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Moreover, the persistent accumulation of inflammatory memory may lead to stem cell dysfunction, resulting in exaggerated immune responses and increased susceptibility to autoimmune diseases (e.g., psoriasis) and chronic inflammatory conditions

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These cell lines are highly tumorigenic and hypermetastatic, which was proven by lung colonization assay

For example, the plastidial MDHAR form is activated by TRXy2, and the activity of a recombinant plastid Arabidopsis MDHAR isoform (MDHAR6) increases in the presence of reduced TRXy, and not other plastidial TRXs (Vanacker et al