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Through high-frequency ctDNA detection, clinicians can detect resistance trends (such as RRM2 copy number doubling) earlier than imaging, and guide the adjustment of treatment plans (such as switching to RRM2 inhibitor 3-AP or combined with METTL3 inhibitor) to avoid ineffective chemotherapy

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Some researchers suggest that acute spikes in plasma glucose trigger this stress (Papachristoforou et al., 2020), while others attribute it to glycemic variability (Rehman and Akash, 2017)

Fatigue and nutrient deficiencies: Food sensitivities can interfere with proper digestion and nutrient absorption, which may lead to deficiencies in key vitamins and minerals

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