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After taking up residence in the islets, macrophages remain in intimate contact with the -cells, where they act as exquisite sensors of the function and viability of -cells (15)

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In addition to its role in the activation of antioxidant and detoxifying enzymes, NF-E2-related factor 2 has been suggested to have a positive role in cancer tumorigenesis and chemoresistance ( Reference Rushworth, Bowles and MacEwan 48 )