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Additionally, obesity and IR both contribute to -cell dysfunction and apoptosis, mechanistically explained by glucotoxicity and increased immunogenicity (the accelerator hypothesis) or by -cell exhaustion due to increased metabolic demand (the overload hypothesis) [23]

Vitamin E is a powerful antioxidant that supports normal blood clotting, tissue repair and normal blood pressure

It may also offer similar effects for bone, skin, and muscle [11]

Front Pharmacol (2023) 14:1208780

The hydrogel, called NO microbubble-capturing hydrogel, was expected to prolong NO retention in the wound area and accelerate the wound healing process (Fig