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Of these, J-difference editing approaches such as MEGA (MEscher-GArwood) (Mescher et al., 1996) combined with a localization scheme such as PRESS (Point-RESolved Spectroscopy) (Bottomley, 1987), together called MEGA-PRESS, have most commonly been used to measure brain GSH (Dwivedi et al., 2020)

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Although the presence of chemo-resistant cells in the core of the organoids highlighted the complexity of tumor microenvironments, and the challenge of overcoming drug resistance, this platform revealed to have high predictive value for therapeutic efficacy of anti-cancer drugs

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