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Inhibition of Pro-Inflammatory Cytokines: KPV has been shown to inhibit the production of pro-inflammatory cytokines, such as TNF-, IL-1, and IL-6

Molecules 26, 1909

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The strongest evidence comes from the DIVINe clinical trial, in which people with diabetic nephropathy taking 1,000 g/day of cyanocobalamin (plus folic acid and B6) experienced significantly faster decline in kidney function than the placebo group over 36 months (5.8 mL/min/1.73 m greater decline, p=0.02