Variants in genes such as those within the Human leukocyte antigen (HLA) region, including specific single nucleotide polymorphisms (SNPs), have been linked to increased susceptibility to UC
Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury
Mechanistically, PGC-1 localizes to subnuclear structures, facilitating its interaction with transcriptional cofactors and coregulators, in which the promyelocytic leukemia (PML) nuclear body constitutes an interface whereby PGC-1 interacts with transcriptional components
388 Peripartum cardiomyopathy (PPCM) occurs globally and is accompanied by systolic dysfunction that presents in late pregnancy or, more commonly, the early postpartum period
Also, ceramide addition has been shown to stabilize interactions between AKT/PKB and PKC via their recruitment membrane rafts or caveolae