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328,329,330,331 CAFs synthesize type I collagen and intensify tumor invasiveness by promoting BM remodeling and EMT

Vitamin K cannot be produced physiologically by human cells but can be synthesized by the gut microbiota (vitamin K2 or menaquinone) ( Vitamin K deficiency is rare in adults, primarily due to malabsorption, total parenteral nutrition, or antibiotic use (which reduces gut bacteria production of vitamin K), a common issue in oncology wards