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Motif enrichment of differentially expressed genes was performed using HOMER (findMotifsGenome.pl)

Research indicates that carnitine insufficiency develops under conditions of sustained metabolic stress, including advanced age, obesity, diabetes, and chronic disease states

It is found throughout the body in blood, saliva, and urine, but its levels decline significantly with age

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In the exhaled breath condensate of COPD patients, the levels of oxidative stress markers such as hydrogen peroxide (H 2 O 2 ) and 8-isoprostaglandin (8-IP) are significantly increased