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Although direct evidence of CHAC1 involvement in human neurodegeneration remains limited, its well-established role in GSH catabolism positions it mechanistically at the intersection of ferroptotic pathways

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Patients with Beclin-1 Y333 phosphorylation also display increased chemotherapy resistance and poor prognosis (275)

Or could new, unexpected side effects emerge from the interaction

Only about 17% of patients under 10 years of age are found to have neuropsychiatric symptoms at presentation, whereas in patients presenting after 18 years of age, 74% experience neurologic manifestations.2,20 It is usually after 10 years of age that patients may manifest evidence of involvement of the other organ systems such as renal, hematologic, and endocrine (Figure 252)