However, despite the biochemical plausibility, optimal dose, recommended timing of administration, and appropriate choice of outcome measures, no significant changes were observed in oxidative stress biomarkers or erythrocyte glutathione concentrations following 4 weeks of oral GSH supplementation in healthy adults
These substances can create oxidative stress, harm mitochondria, and even damage DNA
doi: 36
In fact, ROS-modulating therapies share certain similarities with existing treatments such as chemotherapy and immunotherapy, that is, pro-oxidative stress strategies to further kill tumor cells and other cells, which has been recognized as a promising approach to improve treatment outcomes for decades [564, 565]
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