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Effects of supplementation with the fat-soluble vitamins E and D on fasting flow-mediated vasodilation in adults: a meta-analysis of randomized controlled trials

Week 1: Early Pharmacodynamic Changes What the trials documented: The Phase 1b combination study measured reduced food intake and slowed gastric emptying among the earliest pharmacodynamic signals after dosing began, while the dose was still at the lowest titration step (Enebo et al., 2021)