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However, similar to the effects of fasting regimens, reduction in insulin sensitivity was observed in a short-term time frame so further studies are required for longer-term impact assessment

doi: 10.1111/j.1477-2574.2009.00038.x

PI3Ks regulate the activation of macropinocytosis though phosphorylation and activation of phosphatidylinositol [3,4,5]-triphosphate (PIP3) and macropinosome formation involves PIP3 association with actin-rich membrane ruffles in a process that utilize cortical actin which lies just underneath the plasma membrane [74]

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