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Advancements in ROS imaging, such as bioluminescent sensors, protein-based reporters, and hybrid modalities like PET-ROS imaging, are emerging but remain limited by sensitivity, specificity, and tissue accessibility (Hawkins and Davies, 2019

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CDS is characterized by excessive accumulation of TAG in the cells of many organs, and the clinical manifestations include ichthyosis, cataracts, ataxia, neurosensory hearing loss, and mental retardation (67)