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Therefore, a key element in improving cosmetic formulations is research into the skin permeation of compounds with therapeutic effects

Cosmetic outcomes reported for topical use Pickart and Margolinas reviews summarize controlled cosmetic studies in which topical GHK-Cu formulations were reported to tighten loose skin, improve elasticity, increase skin density and firmness, reduce fine lines and wrinkles, reduce photodamage, and reduce hyperpigmentation, alongside increased keratinocyte proliferation

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It mimics ghrelin and binds to the ghrelin receptor (GHSR) in the brain, selectively stimulating GH release from the pituitary gland, which increases plasma GH levels