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The complexity of neurosteroid-mediated effects, for instance gating of GABA A R (109, 135139) and subunit-specific modulation of glycine and NMDARs (140), suggest the likelihood of multiple binding sites that contribute to potentiating and inhibitory effects ( A Rs also appears to involve modulation of subunit-containing receptors which play a role in tonic inhibition (141145)

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TB-500, a synthetic analog of thymosin beta-4, has demonstrated benefits in modulating actin dynamics, improving cell migration, and promoting angiogenesis

10.1016/j.addr.2023.114763 Adv