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(PubMed) McMahon JA, Green TJ, Skeaff CM, Knight RG, Mann JI, Williams SM

While existing studies highlight the involvement of nitric oxide bioavailability, calcium channel regulation, antioxidant systems, and the RhoA/ROCK and prostaglandin pathways, further mechanistic investigations are required to delineate tissue-specific effects and interactions with conventional pharmacological agents

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The latter represents a central perfusion deficit or hemodynamic disorder, characterized by distinct mechanisms, although both conditions may coexist