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Moreover, neutrophil elastase inhibitors have been shown to activate the Keap1/Nrf2 pathway in obese asthmatic rats, thereby enhancing antioxidant enzyme activity and reducing oxidative stress [106]

while neither compound is known to impair lactation, the concentrated doses delivered by weekly injections may alter milk taste or infant gastrointestinal tolerance

In this regard, specific therapeutic interventions currently under investigation include anti-inflammatory agents (e.g., steroids), antioxidants (e.g., tocopherols, melatonin, N-acetylcysteine, nitric oxide synthase inhibitors), protease inhibitors (e.g., doxycycline, aprotinin, ilomastat), surfactant replacement, and bronchodilators

Diab Obesity 2 (3), 000140

[Google Scholar] 29.Zeneroli ML, Baraldi M, Ventura E