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It has been shown that low-frequency recombination with silent tpsC cassettes, which share sequence similarity with the central region of tpsA but show an entirely different 3-terminal sequence, may introduce different toxic modules at the variable C-terminus of meningococcal TpsA ( tpsC cassettes and the cognate IORFs could confer increased plasticity to a genomic region that appears to be involved in the evolution of virulence in meningococcus

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