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Amyotrophic lateral sclerosis immunoglobulins G enhance the mobility of Lysotracker-labelled vesicles in cultured rat astrocytes

While a healthy, intact BBB tightly restricts the movement of these substances into the CNS compartment, these, and other myeloid-responsive factors, such as cytokines, are not fully restricted from entering the CNS, which may compromise BBB integrity through stimulation of perivascular Ms and microglia

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In animal studies, administration of BPC 157 following the damage caused by these drugs has shown that damage such as ventricular tachycardia, bradycardia, T wave elevation, QTc prolongation and asystole can be completely resolved in mice

Brinkmann V, Reichard U, Goosmann C et al (2004) Neutrophil extracellular traps kill bacteria