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doi: 10.7554/eLife.83207, 4 AytonS.BartonD.BrewB.BrodtmannA.ClarnetteR.DesmondP.et al

Diabetes mellitus refers to metabolic diseases which are characterized by hyperglycemia that develops as a result of impairment in insulin secretion, insulin action, or both [5, 6]

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4 This facilitates oxygen unloading at the tissue level 6 and supports redox balance by favoring fluxes through glycolysis at the expense of the pentose phosphate pathway (PPP), 4 thereby limiting NADPH generation and thus NADPH-dependent glutathione recycling

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