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FOXO4-DRI at the heart of longevity research Some cells in the body behave like silent saboteurs

Gevi F, Zolla L, Gabriele S, Persico AM

Oxidative stress, generated by activated immune cells, produces reactive oxygen species (ROS) and nitric oxide, causing DNA damage in gametes and embryos, reducing sperm motility, and impairing fertilization ( 2.3 Oxidative stress and ferroptosis in endometriosis Ferroptosis, a novel iron-dependent programmed cell death characterized by the accumulation of lipid peroxides, is distinct from apoptosis, necrosis, and autophagy, and has been closely linked to female infertility, including endometriosis-associated infertility ( 2+ + H 2 O 2 Fe 3+ + OH + OH), producing highly toxic hydroxyl radicals that target lipids, proteins, and nucleic acids, thereby exacerbating oxidative stress

doi:10.1016/j.scitotenv.2015.04.099 Givens RS, Gingrich J, Mecklenburg S (1986) Photochemistry of flunitrazepam: a product and model study

10 nM) were added to port A, 22 l oligomycin (O4876