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[DOI] [PMC free article] [PubMed] [Google Scholar] 126.Singh S, Padovani D, Leslie RA, Chiku T, Banerjee R

Many other factors can upregulate the expression level and activity of arginase, such as lipopolysaccharide, TNF-, glucose, thrombin, hypoxia and angiotensin II [reviewed in Pernow and Jung (2013)]

Within this framework, LPS and histamine exert a critical priming effect: circulating LPS lowers the inflammatory activation threshold of peripheral tissues, while rumen-derived histamine promotes microvascular dysregulation and lamellar hypoxia

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