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When erastin acts on lung cancer A549 cells, it upregulates and activates P53, thereby transcriptionally activating its downstream target genes (including P21 and bax), thereby inhibiting SLC7A11 activity, inducing ROS accumulation and eventually leading to ferroptosis 48

Proc Am Assoc Cancer Res 45:876-877, 2004

Gallstone formation and gallbladder mucosal changes in mice fed a lithogenic diet

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