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This suggests that CaOx-exo exacerbates pre-existing renal injury caused by kidney stones, potentially through enhanced macrophage phagocytosis or upregulated expression of scavenger receptors, thereby increasing the uptake of exogenous exosomes [32]

UPR-driven tumor dormancy and therapeutic resistance Beyond its role in active tumor growth, the UPR plays a pivotal role in cancer cell dormancy, long-term survival, and resistance to anticancer therapies

Bryan Johnson is a tech entrepreneur, futurist, and biohacker best known for founding Kernel, a company focused on developing advanced neurotechnology, and Braintree, a payment processing company acquired by PayPal for $800 million

KEAP1 (kelch like ECH associated protein 1), an enzyme often mutated in lung cancer, interacts with NFE2L2, leading to NFE2L2 degradation [154, 155]